Spravato (Esketamine)

Rapid relief when depression will not wait.

Spravato is an FDA-approved nasal-spray esketamine treatment for treatment-resistant depression, administered on-site under medical monitoring. For some patients, symptoms improve in as little as 24 hours.

Request a Consultation
  • FDA-cleared Deep TMS
  • BrainsWay H-Coil
  • 20+ clinicians
  • 2 Main Line locations
  • Most insurance accepted

What is Spravato?

Spravato (esketamine) is a prescription nasal spray FDA-approved for treatment-resistant depression and for depressive symptoms in adults with major depression and acute suicidal ideation. It works on the brain's glutamate system — a different mechanism than traditional antidepressants — which is why it can act far more quickly.

Because of how it works, Spravato is given in our office under the supervision of our care team. You self-administer the spray and are monitored for about two hours afterward. You will need someone to drive you home.

Who Spravato helps

Treatment-resistant depression

Adults who have not responded to two or more antidepressants.

Learn more

Urgent depressive symptoms

Patients who need faster relief than standard medication can provide.

A complement to other care

Often paired with oral antidepressants, therapy, or Deep TMS.

How it works

What to expect at a Spravato visit

  1. 01

    Step 1

    1. Evaluation & approval

    A provider confirms you are a candidate and our billing team secures insurance authorization.

  2. 02

    Step 2

    2. In-office administration

    You self-administer the nasal spray in a comfortable, monitored setting.

  3. 03

    Step 3

    3. Two-hour monitoring

    Our team monitors you for about two hours before you go home (with a driver).

  4. 04

    Step 4

    4. Ongoing schedule

    Treatment usually starts twice weekly, then tapers as you respond.

Insurance and Spravato

Spravato is covered by many insurance plans for treatment-resistant depression, though it typically requires prior authorization. Our billing team handles that for you and verifies your benefits before treatment. We are in-network with Aetna, AmeriHealth, Blue Cross Blue Shield, Cigna, Geisinger, Humana, Independence Blue Cross, Medicare, Optum, TRICARE, UnitedHealthcare, and UPMC, plus 40+ more. See accepted insurance

Spravato — common questions

How fast does Spravato work?

For some patients, depressive symptoms improve in as little as 24 hours — much faster than traditional antidepressants. Response varies, and your provider will set realistic expectations.

Is Spravato the same as ketamine?

Spravato (esketamine) is a specific, FDA-approved formulation derived from ketamine, delivered as a nasal spray in a monitored medical setting. That FDA approval is what makes it insurance-eligible for treatment-resistant depression.

Why do I need a driver?

Spravato can cause temporary dizziness or drowsiness, so you must not drive until the next day. Plan for someone to take you home after each visit.

Could Spravato be your fast track to relief?

Request a consultation and we will confirm candidacy and handle the authorization.

Request a Consultation